Atopic dermatitis is a chronic eczema characterized by its pruritus and dryness. The cause atopic dermatitis is still unknown. But Ig E mediated immediate hypersensitivity reaction ays an importantrole in the pathogenesis of atopic dermatitis.
In order to assess the predominant allergen, serum specific Ig E were measured by Chemiminescent (CLA) in 20 patients with atopic dermatitis.
@ES The results were as follows :
@EN 1. The sex ratio of male to female was 1 : 1 and the mean age was 15.2 years old. There were, according to the clinical variety, 5 cases of infantile type, 8 cases of childhood type, anhd 7 cases of adolescent-adult type.
2. The positive rate of CLA in general was 70%. According to the clinical variety, positive rates were enceountered in 80% of infantile type. 6.7% of childhood type, and 71.4% of adolescent-adult type, respectively.
3. Forty five percent of patients showed positive reactions to two or more allergens while 25% was positive to single allergen.
4. The individual allergen which showed higher rate of positive reaction were D. farinae (25%), D. pteronyssinus (25%), Egg whole (20%), Ragweed (15%), Candida (15%). The positivity of the group of allergens were Pollen (45%), Food (35%),
Microorganism
(25%), Fungi (20%), Dust (10%), Epithelials (5%), Insect (5%) in descending order. The group of inhalant allergens showed higher positive tendency than that of food allergens.
5. The most frequent allergens were Egg whole (40%), Candida (40%) in infantile typ, and D. farinae (57.1%), D. pteronyssinus (57.1%) in adolescent-adult type.
6. According to the clinicalvarity, allergen groups showed higher rate of positive reaction were as follows. Food (60%), pollen (40%), and fungi (40%) in infantile type. Pollen (50%), microorganism (42.9%), and food (42.9%) in adolescent adult
type.
The group of inhalant allergens showed lower rate of positive reaction than that of foood allergens in infantile type, but it was reversed in childhood type and adolescent-adulttype.l
In conclusin. It was suggested that the predominant allerges which might cause or exacerbate atopic dermatitis were egg whole and candida in infantil type, but inhalant allergens are more important than food allrgent with increasisng age.
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